Renoprotection by ACE Inhibition or Aldosterone Blockade Is Blood Pressure–Dependent

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Renoprotection by ACE inhibition or aldosterone blockade is blood pressure-dependent.

Renin-angiotensin-aldosterone system blockade has been shown to protect against renal damage in salt-supplemented, stroke-prone spontaneously hypertensive rats (SHRsp). Based on intermittent tail-cuff blood pressure (BP) measurements, it has been claimed that such protection is BP-independent and mediated by a blockade of the direct tissue-damaging effects of angiotensin and/or aldosterone. BP ...

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ACE2 deficiency modifies renoprotection afforded by ACE inhibition in experimental diabetes.

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Improvement of endothelial dysfunction in experimental heart failure by chronic RAAS-blockade: ACE-inhibition or AT1-receptor blockade?

Chronic heart failure (CHF) is associated with endothelial dysfunction. Activation of the renin-angiotensin-aldosterone system (RAAS) is believed to be important in the deterioration of endothelial dysfunction in CHF through stimulation of oxidative stress. Whereas angiotensin-converting enzyme inhibitors (ACE-I) improve endothelial function in CHF, the effects of angiotensin II AT1-receptor bl...

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Comparative Effects of ACE Inhibition and Calcium Channel Blockade

Background We wished to assess the respective roles of the antihypertensive and blood pressure (BP)-independent effects of antihypertensive drugs on arterial hemodynamics and left ventricular hypertrophy (LVH) in end-stage renal disease (ESRD) patients. Methods and Results In a double-blind study, 24 ESRD patients with LVH were randomized to 12 months' administration of either the angiotensin-c...

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Renoprotection: a matter of blood pressure reduction or agent-characteristics?

Data from recent clinical trials show that lowering of BP reduces the rate of renal function loss in chronic renal disease. There is evidence supporting the assertion that BP lowering obtained by intervention in the renin-angiotensin-aldosterone system (RAAS) has an additive renoprotective effect in both diabetic and nondiabetic renal diseases. However, to dissociate BP-dependent and non-BP-dep...

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ژورنال

عنوان ژورنال: Hypertension

سال: 2003

ISSN: 0194-911X,1524-4563

DOI: 10.1161/01.hyp.0000049881.25304.73